Name

Neovaisseaux choroïdiens inactifs dans la DMLE

The aim of this study was to compare quantitative optical coherence tomography angiography (OCTA) parameters between treatment-naïve quiescent choroidal neovascularizations (CNVs) and previously-treated non-exudative type 1 CNVs, in patients with age-related macular degeneration (AMD).

The eyes included in the study underwent a comprehensive ophthalmological evaluation including best-correct visual acuity, indocyanine green angiography, structural OCT and OCTA. Quantitative OCTA parameters, including vascular density (VD), fractal dimension (FD) and lacunarity (LAC) were calculated. Receiver operating characteristic (ROC) curves, showing the ability of VD, FD, and LAC to discriminate between the two CNV groups, were built.

Forty-two eyes with inactive type 1 CNV were included in the study and then divided into two groups: one (22 eyes) with treatment-naïve quiescent CNVs, the other (20 eyes) with previously-treated non-exudative CNVs. 

On the basis of the ROC analysis, LAC resulted to be the parameter with best discrimination ability, followed by FD and VD (area under the curve= 0.83, 0.78, and 0.62, respectively)

Treatment-naïve quiescent CNVs are low aggressive forms of neovascularization with lower activation rate when compared with previously-treated non-exudative CNVs 

Results suggest that FD and LAC could be used to to discriminate objectively inactive CNVs with different prognosis, in AMD patients.