Name

455 - Microvascularisation rétinienne et adénomes hypophysaires : intérêt de l'OCT angiographie

Pituitary adenoma (PA) is one of the most common causes of benign intracranial masses. Optical coherence tomography angiography (OCTA) is an emerging, non-invasive method to study the microvasculature of the macula and the optic nerve head. The aim of this study was to assess the vasculature changes in the peripapillary and macular areas associated with PA using OCTA.

Retrospective study of 30 eyes of 16 healthy subjects, and 30 eyes of 17 PA patients with good quality OCTA images. PA patients were divided into PA with optic neuropathy (16 eyes) and PA without optic neuropathy (14 eyes). 4.5x4.5 mm disc and 3x3 mm macular angiograms were studied. Whole-image (wiVD), peripapillary (ppVD), and superficial macular vessel densities (mVD) were obtained. Mann-Whitney test and Pearson coefficient were used.

ppVD in PA eyes (47.81 ± 5.31%) was significantly decreased compared to healthy eyes (50.52 ± 2.14 %, p = 0.024). This difference was significant between PA patients with optic neuropathy (mean reduction of peripapillary VD of 10.51%) and healthy subjects whereas there was no significant difference between PA patients without optic neuropathy and healthy subjects. mVD was also significantly reduced in PA eyes (p=0,003).               Pearson’s correlation coefficient showed a correlation between ppVD and RNFL thickness (r=0.76) and between ppVD and automated perimetry mean deviation (r=0.922). Moreover we noticed a correlation between ppVD in inferior of papilla with GCC (r=0.717).

Vessel densities in PA eyes are significantly lower than in healthy eyes. A diminished microvascular network is associated with RNFL thinning and perimetric alterations.

Peripapillary and macular capillary rarefaction in PA eyes could be useful tools to assess the effect of PA on visual function.