Name

281 - Connectivité cérébral aberrant pour les patients de strabisme - L’ analyse de la téories des graphes-

Strabismus patients, despite of altered binocular visual function, can perform visual processing in practice. It is difficult to estimate their compensations at clinical circumstances. Recently neuroimaging study is focusing on brain connectivity as a network.  Graph theoretical analysis compared strabismus and normal control groups estimating their brain network by using MRI

Strabismus group, having history of strabismus surgery, and age sex matched control group were examined with 3T clinical MR (SIEMENS, MAGNETOM A Trio Tim) scanner.  Resting state functional magnetic resonance imaging (rs-fMRI) was acquired to explore functional connectivity. Each rs-fMRI session was about 10 minutes with determined 90 cortical regions using automated anatomical labeling (AAL). Functional brain connectivity matrix for each subject was calculated by using DPABI (1) software developed by Beijing Normal University. Matrices of strabismus and control groups were statistically compared by using Graphvar software (2).

65 connections were statistically different between two groups, of which 20 was significantly increased in control group and 45 in strabismus group. Left lingual gyrus shows statistically different several regional indices of graph theory. Degree, characteristic path length and betweenness centrality exceed in control group, whereas clustering coefficient and local efficiency exceed in strabismus group.

Functional brain connectivity analysis based on graph theory show aberrant connectivity for strabismus group. Some regional indices of graph theory show predominance in strabismus.

Our result suggest that strabismus brain compensate visual processing in spite of lack or attenuation of binocular function.